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Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. [electronic resource] by
- Meredith, Jere E
- Sankaranarayanan, Sethu
- Guss, Valerie
- Lanzetti, Anthony J
- Berisha, Flora
- Neely, Robert J
- Slemmon, J Randall
- Portelius, Erik
- Zetterberg, Henrik
- Blennow, Kaj
- Soares, Holly
- Ahlijanian, Michael
- Albright, Charles F
Producer: 20140802
In:
PloS one vol. 8
Availability: No items available.
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7.
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Tau transgenic mice as models for cerebrospinal fluid tau biomarkers. [electronic resource] by
- Barten, Donna M
- Cadelina, Gregory W
- Hoque, Nina
- DeCarr, Lynn B
- Guss, Valerie L
- Yang, Ling
- Sankaranarayanan, Sethu
- Wes, Paul D
- Flynn, Marianne E
- Meredith, Jere E
- Ahlijanian, Michael K
- Albright, Charles F
Producer: 20110930
In:
Journal of Alzheimer's disease : JAD vol. 24 Suppl 2
Availability: No items available.
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8.
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Synergistic inhibition of Aβ production by combinations of γ-secretase modulators. [electronic resource] by
- Robertson, Alan S
- Iben, Lawrence G
- Wei, Cong
- Meredith, Jere E
- Drexler, Dieter M
- Banks, Martyn
- Vite, Gregory D
- Olson, Richard E
- Thompson, Lorin A
- Albright, Charles F
- Ahlijanian, Michael K
- Toyn, Jeremy H
Producer: 20180515
In:
European journal of pharmacology vol. 812
Availability: No items available.
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9.
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Viable mouse gene ablations that robustly alter brain Aβ levels are rare. [electronic resource] by
- Toyn, Jeremy H
- Lin, Xu-Alan
- Thompson, Mark W
- Guss, Valerie
- Meredith, Jere E
- Sankaranarayanan, Sethu
- Barrezueta, Nestor
- Corradi, John
- Majumdar, Antara
- Small, Daniel L
- Hansard, Melissa
- Lanthorn, Thomas
- Westphal, Ryan S
- Albright, Charles F
Producer: 20110926
In:
BMC neuroscience vol. 11
Availability: No items available.
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10.
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Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. [electronic resource] by
- Thompson, Lorin A
- Liauw, Ann Y
- Ramanjulu, Mercy M
- Kasireddy-Polam, Padmaja
- Mercer, Stephen E
- Maduskuie, Thomas P
- Glicksman, Marcie
- Roach, Arthur H
- Meredith, Jere E
- Liu, Rui-Qin
- Combs, Andrew P
- Higaki, Jeffrey N
- Cordell, Barbara
- Seiffert, Dietmar
- Zaczek, Robert C
- Robertson, David W
- Olson, Richard E
Producer: 20060626
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
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11.
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Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE). [electronic resource] by
- Boy, Kenneth M
- Guernon, Jason M
- Wu, Yong-Jin
- Zhang, Yunhui
- Shi, Joe
- Zhai, Weixu
- Zhu, Shirong
- Gerritz, Samuel W
- Toyn, Jeremy H
- Meredith, Jere E
- Barten, Donna M
- Burton, Catherine R
- Albright, Charles F
- Good, Andrew C
- Grace, James E
- Lentz, Kimberley A
- Olson, Richard E
- Macor, John E
- Thompson, Lorin A
Producer: 20160811
In:
Bioorganic & medicinal chemistry letters vol. 25
Availability: No items available.
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12.
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Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE). [electronic resource] by
- Boy, Kenneth M
- Guernon, Jason M
- Shi, Jianliang
- Toyn, Jeremy H
- Meredith, Jere E
- Barten, Donna M
- Burton, Catherine R
- Albright, Charles F
- Marcinkeviciene, Jovita
- Good, Andrew C
- Tebben, Andrew J
- Muckelbauer, Jodi K
- Camac, Daniel M
- Lentz, Kimberley A
- Bronson, Joanne J
- Olson, Richard E
- Macor, John E
- Thompson, Lorin A
Producer: 20120213
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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13.
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Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis. [electronic resource] by
- Gerritz, Samuel W
- Zhai, Weixu
- Shi, Shuhao
- Zhu, Shirong
- Toyn, Jeremy H
- Meredith, Jere E
- Iben, Lawrence G
- Burton, Catherine R
- Albright, Charles F
- Good, Andrew C
- Tebben, Andrew J
- Muckelbauer, Jodi K
- Camac, Daniel M
- Metzler, William
- Cook, Lynda S
- Padmanabha, Ramesh
- Lentz, Kimberley A
- Sofia, Michael J
- Poss, Michael A
- Macor, John E
- Thompson, Lorin A
Producer: 20130226
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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14.
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P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice. [electronic resource] by
- Meredith, Jere E
- Thompson, Lorin A
- Toyn, Jeremy H
- Marcin, Lawrence
- Barten, Donna M
- Marcinkeviciene, Jovita
- Kopcho, Lisa
- Kim, Young
- Lin, Alan
- Guss, Valerie
- Burton, Catherine
- Iben, Lawrence
- Polson, Craig
- Cantone, Joe
- Ford, Michael
- Drexler, Dieter
- Fiedler, Tracey
- Lentz, Kimberley A
- Grace, James E
- Kolb, Janet
- Corsa, Jason
- Pierdomenico, Maria
- Jones, Kelli
- Olson, Richard E
- Macor, John E
- Albright, Charles F
Producer: 20080812
In:
The Journal of pharmacology and experimental therapeutics vol. 326
Availability: No items available.
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15.
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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor. [electronic resource] by
- Gillman, Kevin W
- Starrett, John E
- Parker, Michael F
- Xie, Kai
- Bronson, Joanne J
- Marcin, Lawrence R
- McElhone, Kate E
- Bergstrom, Carl P
- Mate, Robert A
- Williams, Richard
- Meredith, Jere E
- Burton, Catherine R
- Barten, Donna M
- Toyn, Jeremy H
- Roberts, Susan B
- Lentz, Kimberley A
- Houston, John G
- Zaczek, Robert
- Albright, Charles F
- Decicco, Carl P
- Macor, John E
- Olson, Richard E
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 1
Availability: No items available.
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16.
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Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. [electronic resource] by
- Barten, Donna M
- Fanara, Patrizia
- Andorfer, Cathy
- Hoque, Nina
- Wong, P Y Anne
- Husted, Kristofor H
- Cadelina, Gregory W
- Decarr, Lynn B
- Yang, Ling
- Liu, Victoria
- Fessler, Chancy
- Protassio, Joan
- Riff, Timothy
- Turner, Holly
- Janus, Christopher G
- Sankaranarayanan, Sethu
- Polson, Craig
- Meredith, Jere E
- Gray, Gemma
- Hanna, Amanda
- Olson, Richard E
- Kim, Soong-Hoon
- Vite, Gregory D
- Lee, Francis Y
- Albright, Charles F
Producer: 20120803
In:
The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 32
Availability: No items available.
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17.
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Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1. [electronic resource] by
- Marcin, Lawrence R
- Higgins, Mendi A
- Zusi, F Christopher
- Zhang, Yunhui
- Dee, Michael F
- Parker, Michael F
- Muckelbauer, Jodi K
- Camac, Daniel M
- Morin, Paul E
- Ramamurthy, Vidhyashankar
- Tebben, Andrew J
- Lentz, Kimberley A
- Grace, James E
- Marcinkeviciene, Jovita A
- Kopcho, Lisa M
- Burton, Catherine R
- Barten, Donna M
- Toyn, Jeremy H
- Meredith, Jere E
- Albright, Charles F
- Bronson, Joanne J
- Macor, John E
- Thompson, Lorin A
Producer: 20110414
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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18.
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Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. [electronic resource] by
- Thompson, Lorin A
- Shi, Jianliang
- Decicco, Carl P
- Tebben, Andrew J
- Olson, Richard E
- Boy, Kenneth M
- Guernon, Jason M
- Good, Andrew C
- Liauw, Ann
- Zheng, Changsheng
- Copeland, Robert A
- Combs, Andrew P
- Trainor, George L
- Camac, Daniel M
- Muckelbauer, Jodi K
- Lentz, Kimberley A
- Grace, James E
- Burton, Catherine R
- Toyn, Jeremy H
- Barten, Donna M
- Marcinkeviciene, Jovita
- Meredith, Jere E
- Albright, Charles F
- Macor, John E
Producer: 20120213
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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19.
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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481. [electronic resource] by
- Boy, Kenneth M
- Guernon, Jason M
- Zuev, Dmitry S
- Xu, Li
- Zhang, Yunhui
- Shi, Jianliang
- Marcin, Lawrence R
- Higgins, Mendi A
- Wu, Yong-Jin
- Krishnananthan, Subramaniam
- Li, Jianqing
- Trehan, Ashok
- Smith, Daniel
- Toyn, Jeremy H
- Meredith, Jere E
- Burton, Catherine R
- Kimura, S Roy
- Zvyaga, Tatyana
- Zhuo, Xiaoliang
- Lentz, Kimberley A
- Grace, James E
- Denton, Rex
- Morrison, John S
- Mathur, Arvind
- Albright, Charles F
- Ahlijanian, Michael K
- Olson, Richard E
- Thompson, Lorin A
- Macor, John E
Publication details: ACS medicinal chemistry letters Mar 2019
In:
ACS medicinal chemistry letters vol. 10
Availability: No items available.
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20.
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Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. [electronic resource] by
- Toyn, Jeremy H
- Boy, Kenneth M
- Raybon, Joseph
- Meredith, Jere E
- Robertson, Alan S
- Guss, Valerie
- Hoque, Nina
- Sweeney, Francis
- Zhuo, Xiaoliang
- Clarke, Wendy
- Snow, Kimberly
- Denton, R Rex
- Zuev, Dmitry
- Thompson, Lorin A
- Morrison, John
- Grace, James
- Berisha, Flora
- Furlong, Michael
- Wang, Jun-Sheng
- Lentz, Kimberly A
- Padmanabha, Ramesh
- Cook, Lynda
- Wei, Cong
- Drexler, Dieter M
- Macor, John E
- Albright, Charlie F
- Gasior, Maciej
- Olson, Richard E
- Hong, Quan
- Soares, Holly D
- AbuTarif, Malaz
- Ahlijanian, Michael K
Producer: 20170523
In:
The Journal of pharmacology and experimental therapeutics vol. 358
Availability: No items available.
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