Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase. [electronic resource]
Producer: 20030124Description: 569-73 p. digitalISSN:- 0006-291X
- Acetylcysteine -- analogs & derivatives
- Amyloid Precursor Protein Secretases
- Animals
- Aspartic Acid Endopeptidases
- Cell Line
- Cell-Free System
- Cells, Cultured
- Cysteine Proteinase Inhibitors -- metabolism
- Endopeptidases -- metabolism
- Fibroblasts -- cytology
- Humans
- Membrane Proteins -- genetics
- Mice
- Mice, Knockout
- Molecular Structure
- Mutation
- Protein Structure, Tertiary
- Receptor, Notch1
- Receptors, Cell Surface
- Transcription Factors
- Valine -- metabolism
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Publication Type: Journal Article
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