Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis. [electronic resource]
Producer: 20130226Description: 9208-23 p. digitalISSN:- 1520-4804
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Peptides -- metabolism
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Aspartic Acid Endopeptidases -- antagonists & inhibitors
- Brain -- metabolism
- Cell Line
- Crystallography, X-Ray
- Guanidines -- chemical synthesis
- Humans
- Isoxazoles -- chemical synthesis
- Models, Molecular
- Molecular Structure
- Mutation
- Peptide Fragments -- metabolism
- Protein Binding
- Radioligand Assay
- Rats
- Small Molecule Libraries
- Solid-Phase Synthesis Techniques
- Solutions
- Structure-Activity Relationship
No physical items for this record
Publication Type: Journal Article
There are no comments on this title.
Log in to your account to post a comment.