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Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode. [electronic resource] by
- Gessier, François
- Kallen, Joerg
- Jacoby, Edgar
- Chène, Patrick
- Stachyra-Valat, Thérèse
- Ruetz, Stephan
- Jeay, Sébastien
- Holzer, Philipp
- Masuya, Keiichi
- Furet, Pascal
Producer: 20160517
In:
Bioorganic & medicinal chemistry letters vol. 25
Availability: No items available.
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ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. [electronic resource] by
- Munshi, Neru
- Jeay, Sébastien
- Li, Youzhi
- Chen, Chang-Rung
- France, Dennis S
- Ashwell, Mark A
- Hill, Jason
- Moussa, Magdi M
- Leggett, David S
- Li, Chiang J
Producer: 20100916
In:
Molecular cancer therapeutics vol. 9
Availability: No items available.
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11.
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Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument. [electronic resource] by
- Furet, Pascal
- Masuya, Keiichi
- Kallen, Joerg
- Stachyra-Valat, Thérèse
- Ruetz, Stephan
- Guagnano, Vito
- Holzer, Philipp
- Mah, Robert
- Stutz, Stefan
- Vaupel, Andrea
- Chène, Patrick
- Jeay, Sébastien
- Schlapbach, Achim
Producer: 20170717
In:
Bioorganic & medicinal chemistry letters vol. 26
Availability: No items available.
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12.
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The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. [electronic resource] by
- Reuther, Clemens
- Heinzle, Vera
- Nölting, Svenja
- Herterich, Sabine
- Hahner, Stefanie
- Halilovic, Ensar
- Jeay, Sébastien
- Wuerthner, Jens U
- Aristizabal Prada, Elke Tatjana
- Spöttl, Gerald
- Maurer, Julian
- Auernhammer, Christoph J
Producer: 20190103
In:
Neuroendocrinology vol. 106
Availability: No items available.
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13.
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In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor. [electronic resource] by
- Vaupel, Andrea
- Holzer, Philipp
- Ferretti, Stephane
- Guagnano, Vito
- Kallen, Joerg
- Mah, Robert
- Masuya, Keiichi
- Ruetz, Stephan
- Rynn, Caroline
- Schlapbach, Achim
- Stachyra, Thérèse
- Stutz, Stefan
- Todorov, Milen
- Jeay, Sébastien
- Furet, Pascal
Producer: 20190603
In:
Bioorganic & medicinal chemistry letters vol. 28
Availability: No items available.
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14.
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Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β. [electronic resource] by
- Bielen, Aleksandra
- Perryman, Lara
- Box, Gary M
- Valenti, Melanie
- de Haven Brandon, Alexis
- Martins, Vanessa
- Jury, Alexa
- Popov, Sergey
- Gowan, Sharon
- Jeay, Sebastien
- Raynaud, Florence I
- Hofmann, Francesco
- Hargrave, Darren
- Eccles, Suzanne A
- Jones, Chris
Producer: 20111219
In:
Molecular cancer therapeutics vol. 10
Availability: No items available.
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15.
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Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. [electronic resource] by
- Holzer, Philipp
- Masuya, Keiichi
- Furet, Pascal
- Kallen, Joerg
- Valat-Stachyra, Therese
- Ferretti, Stéphane
- Berghausen, Joerg
- Bouisset-Leonard, Michèle
- Buschmann, Nicole
- Pissot-Soldermann, Carole
- Rynn, Caroline
- Ruetz, Stephan
- Stutz, Stefan
- Chène, Patrick
- Jeay, Sébastien
- Gessier, Francois
Producer: 20151116
In:
Journal of medicinal chemistry vol. 58
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Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors. [electronic resource] by
- Fairhurst, Robin A
- Marsilje, Thomas H
- Stutz, Stefan
- Boos, Andreas
- Niklaus, Michel
- Chen, Bei
- Jiang, Songchun
- Lu, Wenshuo
- Furet, Pascal
- McCarthy, Clive
- Stauffer, Frédéric
- Guagnano, Vito
- Vaupel, Andrea
- Michellys, Pierre-Yves
- Schnell, Christian
- Jeay, Sébastien
Producer: 20161213
In:
Bioorganic & medicinal chemistry letters vol. 26
Availability: No items available.
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17.
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Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma. [electronic resource] by
- Carita, Guillaume
- Frisch-Dit-Leitz, Estelle
- Dahmani, Ahmed
- Raymondie, Chloé
- Cassoux, Nathalie
- Piperno-Neumann, Sophie
- Némati, Fariba
- Laurent, Cécile
- De Koning, Leanne
- Halilovic, Ensar
- Jeay, Sebastien
- Wylie, Andrew
- Emery, Caroline
- Roman-Roman, Sergio
- Schoumacher, Marie
- Decaudin, Didier
Producer: 20180117
In:
Oncotarget vol. 7
Availability: No items available.
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18.
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Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition. [electronic resource] by
- Bielen, Aleksandra
- Box, Gary
- Perryman, Lara
- Bjerke, Lynn
- Popov, Sergey
- Jamin, Yann
- Jury, Alexa
- Valenti, Melanie
- Brandon, Alexis de Haven
- Martins, Vanessa
- Romanet, Vincent
- Jeay, Sebastien
- Raynaud, Florence I
- Hofmann, Francesco
- Robinson, Simon P
- Eccles, Suzanne A
- Jones, Chris
Producer: 20120727
In:
Proceedings of the National Academy of Sciences of the United States of America vol. 109
Availability: No items available.
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19.
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Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human [electronic resource] by
- Wang, Hui Qin
- Halilovic, Ensar
- Li, Xiaoyan
- Liang, Jinsheng
- Cao, Yichen
- Rakiec, Daniel P
- Ruddy, David A
- Jeay, Sebastien
- Wuerthner, Jens U
- Timple, Noelito
- Kasibhatla, Shailaja
- Li, Nanxin
- Williams, Juliet A
- Sellers, William R
- Huang, Alan
- Li, Fang
Producer: 20180212
In:
eLife vol. 6
Availability: No items available.
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20.
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High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells. [electronic resource] by
- Horn, Thomas
- Ferretti, Stéphane
- Ebel, Nicolas
- Tam, Angela
- Ho, Samuel
- Harbinski, Fred
- Farsidjani, Ali
- Zubrowski, Matthew
- Sellers, William R
- Schlegel, Robert
- Porter, Dale
- Morris, Erick
- Wuerthner, Jens
- Jeay, Sébastien
- Greshock, Joel
- Halilovic, Ensar
- Garraway, Levi A
- Caponigro, Giordano
- Lehár, Joseph
Producer: 20170905
In:
Cancer research vol. 76
Availability: No items available.
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