Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors. [electronic resource]
Producer: 20161213Description: 2057-64 p. digitalISSN:- 1464-3405
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Humans
- Imidazoles -- chemical synthesis
- Mice
- Mice, Nude
- Molecular Structure
- NIH 3T3 Cells
- Neoplasms, Experimental -- drug therapy
- Protein Kinase Inhibitors -- chemical synthesis
- Pyrazines -- chemical synthesis
- Pyrimidines -- chemical synthesis
- Pyrroles -- chemical synthesis
- Receptor, IGF Type 1 -- antagonists & inhibitors
- Structure-Activity Relationship
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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