Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. [electronic resource]
Producer: 20151116Description: 6348-58 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Clinical Trials, Phase I as Topic
- Drug Discovery
- Humans
- Isoquinolines -- chemical synthesis
- Piperazines -- chemical synthesis
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Rats
- Structure-Activity Relationship
- Tumor Suppressor Protein p53 -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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