Your search returned 36 results.

Results
	1.	Preparation and properties of clickable amino analogues of the duocarmycins: factors that affect the efficiency of their fluorescent labelling of DNA. [electronic resource] by Tercel, Moana McManaway, Sarah P Liyanage, H D Sarath Pruijn, Frederik B Producer: 20150514 In: ChemMedChem vol. 9 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	2.	Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: implications for extravascular transport and activity in tumors. [electronic resource] by Hicks, Kevin O Siim, Bronwyn G Pruijn, Frederik B Wilson, William R Producer: 20040709 In: Radiation research vol. 161 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	3.	Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy. [electronic resource] by Stevenson, Ralph J Denny, William A Tercel, Moana Pruijn, Frederik B Ashoorzadeh, Amir Producer: 20120727 In: Journal of medicinal chemistry vol. 55 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	4.	Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures. [electronic resource] by Hicks, Kevin O Pruijn, Frederik B Sturman, Joanna R Denny, William A Wilson, William R Producer: 20031204 In: Cancer research vol. 63 Availability: No items available. Save to lists Add to cart (remove)
	5.	Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting. [electronic resource] by Delahoussaye, Yvette M Hay, Michael P Pruijn, Frederik B Denny, William A Brown, J Martin Producer: 20030708 In: Biochemical pharmacology vol. 65 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	6.	In vitro and in vivo models for evaluation of GDEPT: quantifying bystander killing in cell cultures and tumors. [electronic resource] by Wilson, William R Pullen, Susan M Hogg, Alison Hobbs, Stephen M Pruijn, Frederik B Hicks, Kevin O Producer: 20040301 In: Methods in molecular medicine vol. 90 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	7.	The cytotoxicity of duocarmycin analogues is mediated through alkylation of DNA, not aldehyde dehydrogenase 1: a comment. [electronic resource] by Tercel, Moana McManaway, Sarah P Leung, Euphemia Liyanage, H D Sarath Lu, Guo-Liang Pruijn, Frederik B Producer: 20131108 In: Angewandte Chemie (International ed. in English) vol. 52 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	8.	The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy. [electronic resource] by Stevenson, Ralph J Denny, William A Ashoorzadeh, Amir Pruijn, Frederik B van Leeuwen, Wouter F Tercel, Moana Producer: 20120329 In: Bioorganic & medicinal chemistry vol. 19 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	9.	Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins. [electronic resource] by Tercel, Moana Pruijn, Frederik B O'Connor, Patrick D Liyanage, H D Sarath Atwell, Graham J Alix, Sonia M Producer: 20150518 In: Chembiochem : a European journal of chemical biology vol. 15 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	10.	Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures. [electronic resource] by Hong, Cho R Bogle, Gib Wang, Jingli Patel, Kashyap Pruijn, Frederik B Wilson, William R Hicks, Kevin O Publication details: Frontiers in pharmacology 2018 In: Frontiers in pharmacology vol. 9 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	11.	Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). [electronic resource] by Siim, Bronwyn G Lee, Alan E Shalal-Zwain, Sahar Pruijn, Frederik B McKeage, Mark J Wilson, William R Producer: 20030225 In: Cancer chemotherapy and pharmacology vol. 51 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	12.	The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins. [electronic resource] by Ashoorzadeh, Amir Atwell, Graham J Pruijn, Frederik B Wilson, William R Tercel, Moana Denny, William A Stevenson, Ralph J Producer: 20120208 In: Bioorganic & medicinal chemistry vol. 19 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	13.	Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures. [electronic resource] by Pruijn, Frederik B Sturman, Joanna R Liyanage, H D Sarath Hicks, Kevin O Hay, Michael P Wilson, William R Producer: 20050405 In: Journal of medicinal chemistry vol. 48 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	14.	Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence. [electronic resource] by Su, Jiechuang Gu, Yongchuan Pruijn, Frederik B Smaill, Jeff B Patterson, Adam V Guise, Christopher P Wilson, William R Producer: 20140221 In: The Journal of biological chemistry vol. 288 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	15.	Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine. [electronic resource] by Hicks, Kevin O Myint, Hilary Patterson, Adam V Pruijn, Frederik B Siim, Bronwyn G Patel, Kashyap Wilson, William R Producer: 20071109 In: International journal of radiation oncology, biology, physics vol. 69 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	16.	Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation. [electronic resource] by Helsby, Nuala A Wheeler, S James Pruijn, Frederik B Palmer, Brian D Yang, Shangjin Denny, William A Wilson, William R Producer: 20040323 In: Chemical research in toxicology vol. 16 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	17.	Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317. [electronic resource] by Siim, Bronwyn G Pruijn, Frederik B Sturman, Joanna R Hogg, Alison Hay, Michael P Brown, J Martin Wilson, William R Producer: 20040402 In: Cancer research vol. 64 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	18.	Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport. [electronic resource] by Hay, Michael P Hicks, Kevin O Pruijn, Frederik B Pchalek, Karin Siim, Bronwyn G Wilson, William R Denny, William A Producer: 20080310 In: Journal of medicinal chemistry vol. 50 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	19.	Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy. [electronic resource] by Atwell, Graham J Yang, Shangjin Pruijn, Frederik B Pullen, Susan M Hogg, Alison Patterson, Adam V Wilson, William R Denny, William A Producer: 20070427 In: Journal of medicinal chemistry vol. 50 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	20.	Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy. [electronic resource] by Tercel, Moana Lee, Ho H Mehta, Sunali Y Youte Tendoung, Jean-Jacques Bai, Sally Y Liyanage, H D Sarath Pruijn, Frederik B Producer: 20170801 In: Journal of medicinal chemistry vol. 60 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)

Refine your search

Availability

Authors

Topics

Languages

Your search returned 36 results.