Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy. [electronic resource]
Producer: 20070427Description: 1197-212 p. digitalISSN:- 0022-2623
- Animals
- Antineoplastic Agents, Alkylating -- chemical synthesis
- Bystander Effect
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Enzyme Activation
- Escherichia coli Proteins -- genetics
- Female
- Genetic Therapy
- Humans
- Least-Squares Analysis
- Male
- Mice
- Mice, Nude
- Multivariate Analysis
- Nitrogen Mustard Compounds -- chemical synthesis
- Nitroreductases -- genetics
- Prodrugs -- chemical synthesis
- Quantitative Structure-Activity Relationship
- Transplantation, Heterologous
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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