Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy. [electronic resource]
Producer: 20120727Description: 2780-802 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents, Alkylating -- chemical synthesis
- Cell Hypoxia
- Cell Line, Tumor
- Combined Modality Therapy
- Drug Screening Assays, Antitumor
- Humans
- Indoles -- chemical synthesis
- Male
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Neoplasms -- drug therapy
- Neoplasms, Experimental -- drug therapy
- Nitro Compounds -- chemical synthesis
- Prodrugs -- chemical synthesis
- Structure-Activity Relationship
- Sulfonic Acids -- chemistry
- Transplantation, Heterologous
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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