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The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents. [electronic resource] by
- Guilloteau, Jean-Pierre
- Mathieu, Magali
- Giglione, Carmela
- Blanc, Véronique
- Dupuy, Alain
- Chevrier, Miline
- Gil, Patricia
- Famechon, Alain
- Meinnel, Thierry
- Mikol, Vincent
Producer: 20020909
In:
Journal of molecular biology vol. 320
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Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy. [electronic resource] by
- Keil, Stefanie
- Matter, Hans
- Schönafinger, Karl
- Glien, Maike
- Mathieu, Magali
- Marquette, Jean-Pierre
- Michot, Nadine
- Haag-Diergarten, Silke
- Urmann, Matthias
- Wendler, Wolfgang
Producer: 20110721
In:
ChemMedChem vol. 6
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Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation. [electronic resource] by
- Hopkins, Corey
- Neuenschwander, Kent
- Scotese, Anthony
- Jackson, Sharon
- Nieduzak, Thaddeus
- Pauls, Henry
- Liang, Guyan
- Sides, Keith
- Cramer, Dona
- Cairns, Jennifer
- Maignan, Sebastien
- Mathieu, Magali
Producer: 20050324
In:
Bioorganic & medicinal chemistry letters vol. 14
Availability: No items available.
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Differential Water Thermodynamics Determine PI3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications. [electronic resource] by
- Robinson, Daniel
- Bertrand, Thomas
- Carry, Jean-Christophe
- Halley, Frank
- Karlsson, Andreas
- Mathieu, Magali
- Minoux, Hervé
- Perrin, Marc-Antoine
- Robert, Benoit
- Schio, Laurent
- Sherman, Woody
Producer: 20170731
In:
Journal of chemical information and modeling vol. 56
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Structure-based library design and the discovery of a potent and selective mast cell β-tryptase inhibitor as an oral therapeutic agent. [electronic resource] by
- Liang, Guyan
- Aldous, Suzanne
- Merriman, Gregory
- Levell, Julian
- Pribish, James
- Cairns, Jennifer
- Chen, Xin
- Maignan, Sebastien
- Mathieu, Magali
- Tsay, Joseph
- Sides, Keith
- Rebello, Sam
- Whitely, Brian
- Morize, Isabelle
- Pauls, Henry W
Producer: 20120824
In:
Bioorganic & medicinal chemistry letters vol. 22
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Molecular shape and medicinal chemistry: a perspective. [electronic resource] by
- Nicholls, Anthony
- McGaughey, Georgia B
- Sheridan, Robert P
- Good, Andrew C
- Warren, Gregory
- Mathieu, Magali
- Muchmore, Steven W
- Brown, Scott P
- Grant, J Andrew
- Haigh, James A
- Nevins, Neysa
- Jain, Ajay N
- Kelley, Brian
Producer: 20100622
In:
Journal of medicinal chemistry vol. 53
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Automated harvesting and processing of protein crystals through laser photoablation. [electronic resource] by
- Zander, Ulrich
- Hoffmann, Guillaume
- Cornaciu, Irina
- Marquette, Jean-Pierre
- Papp, Gergely
- Landret, Christophe
- Seroul, Gaël
- Sinoir, Jérémy
- Röwer, Martin
- Felisaz, Frank
- Rodriguez-Puente, Sonia
- Mariaule, Vincent
- Murphy, Peter
- Mathieu, Magali
- Cipriani, Florent
- Márquez, José Antonio
Producer: 20161214
In:
Acta crystallographica. Section D, Structural biology vol. 72
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Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase. [electronic resource] by
- Hopkins, Corey R
- Czekaj, Mark
- Kaye, Steven S
- Gao, Zhongli
- Pribish, James
- Pauls, Henry
- Liang, Guyan
- Sides, Keith
- Cramer, Dona
- Cairns, Jennifer
- Luo, Yongyi
- Lim, Heng-Keang
- Vaz, Roy
- Rebello, Sam
- Maignan, Sebastian
- Dupuy, Alain
- Mathieu, Magali
- Levell, Julian
Producer: 20051031
In:
Bioorganic & medicinal chemistry letters vol. 15
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A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. [electronic resource] by
- Ronan, Baptiste
- Flamand, Odile
- Vescovi, Lionel
- Dureuil, Christine
- Durand, Laurence
- Fassy, Florence
- Bachelot, Marie-France
- Lamberton, Annabelle
- Mathieu, Magali
- Bertrand, Thomas
- Marquette, Jean-Pierre
- El-Ahmad, Youssef
- Filoche-Romme, Bruno
- Schio, Laurent
- Garcia-Echeverria, Carlos
- Goulaouic, Hélène
- Pasquier, Benoit
Producer: 20150122
In:
Nature chemical biology vol. 10
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Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase. [electronic resource] by
- Jackson, Sharon A
- Sahni, Sukhveen
- Lee, Lan
- Luo, Yongyi
- Nieduzak, Thaddeus R
- Liang, Guyan
- Chiang, Yulin
- Collar, Nicola
- Fink, David
- He, Wei
- Laoui, Abdelazize
- Merrill, Jean
- Boffey, Ray
- Crackett, Peter
- Rees, Bryan
- Wong, Melanie
- Guilloteau, Jean-Pierre
- Mathieu, Magali
- Rebello, Sam S
Producer: 20050919
In:
Bioorganic & medicinal chemistry vol. 13
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Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions. [electronic resource] by
- Moulin, Aaron
- Mathieu, Magali
- Lawrence, Catherine
- Bigelow, Russell
- Levine, Mark
- Hamel, Christine
- Marquette, Jean-Piere
- Le Parc, Josiane
- Loux, Christophe
- Ferrari, Paul
- Capdevila, Cecile
- Dumas, Jacques
- Dumas, Bruno
- Rak, Alexey
- Bird, Julie
- Qiu, Huawei
- Pan, Clark Q
- Edmunds, Tim
- Wei, Ronnie R
Producer: 20151001
In:
Protein science : a publication of the Protein Society vol. 23
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Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. [electronic resource] by
- Deng, Gejing
- Shen, Junqing
- Yin, Ming
- McManus, Jessica
- Mathieu, Magali
- Gee, Patricia
- He, Timothy
- Shi, Chaomei
- Bedel, Olivier
- McLean, Larry R
- Le-Strat, Frank
- Zhang, Ying
- Marquette, Jean-Pierre
- Gao, Qiang
- Zhang, Bailin
- Rak, Alexey
- Hoffmann, Dietmar
- Rooney, Eamonn
- Vassort, Aurelie
- Englaro, Walter
- Li, Yi
- Patel, Vinod
- Adrian, Francisco
- Gross, Stefan
- Wiederschain, Dmitri
- Cheng, Hong
- Licht, Stuart
Producer: 20150421
In:
The Journal of biological chemistry vol. 290
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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3 [electronic resource] by
- El-Ahmad, Youssef
- Tabart, Michel
- Halley, Frank
- Certal, Victor
- Thompson, Fabienne
- Filoche-Rommé, Bruno
- Gruss-Leleu, Florence
- Muller, Claire
- Brollo, Maurice
- Fabien, Laurence
- Loyau, Véronique
- Bertin, Luc
- Richepin, Patrick
- Pilorge, Fabienne
- Desmazeau, Pascal
- Girardet, Chrystelle
- Beccari, Sylvie
- Louboutin, Audrey
- Lebourg, Gilles
- Le-Roux, Jacques
- Terrier, Corinne
- Vallée, François
- Steier, Valérie
- Mathieu, Magali
- Rak, Alexey
- Abecassis, Pierre-Yves
- Vicat, Pascale
- Benard, Tsiala
- Bouaboula, Monsif
- Sun, Fangxian
- Shomali, Maysoun
- Hebert, Andrew
- Levit, Mikhail
- Cheng, Hong
- Courjaud, Albane
- Ginesty, Celine
- Perrault, Christelle
- Garcia-Echeverria, Carlos
- McCort, Gary
- Schio, Laurent
Producer: 20200727
In:
Journal of medicinal chemistry vol. 63
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16.
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Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. [electronic resource] by
- Pasquier, Benoit
- El-Ahmad, Youssef
- Filoche-Rommé, Bruno
- Dureuil, Christine
- Fassy, Florence
- Abecassis, Pierre-Yves
- Mathieu, Magali
- Bertrand, Thomas
- Benard, Tsiala
- Barrière, Cédric
- El Batti, Samira
- Letallec, Jean-Philippe
- Sonnefraud, Véronique
- Brollo, Maurice
- Delbarre, Laurence
- Loyau, Véronique
- Pilorge, Fabienne
- Bertin, Luc
- Richepin, Patrick
- Arigon, Jérôme
- Labrosse, Jean-Robert
- Clément, Jacques
- Durand, Florence
- Combet, Romain
- Perraut, Pierre
- Leroy, Vincent
- Gay, Frédéric
- Lefrançois, Dominique
- Bretin, François
- Marquette, Jean-Pierre
- Michot, Nadine
- Caron, Anne
- Castell, Christelle
- Schio, Laurent
- McCort, Gary
- Goulaouic, Hélène
- Garcia-Echeverria, Carlos
- Ronan, Baptiste
Producer: 20150427
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers. [electronic resource] by
- Certal, Victor
- Carry, Jean-Christophe
- Halley, Frank
- Virone-Oddos, Angela
- Thompson, Fabienne
- Filoche-Rommé, Bruno
- El-Ahmad, Youssef
- Karlsson, Andreas
- Charrier, Véronique
- Delorme, Cécile
- Rak, Alexey
- Abecassis, Pierre-Yves
- Amara, Céline
- Vincent, Loïc
- Bonnevaux, Hélène
- Nicolas, Jean-Paul
- Mathieu, Magali
- Bertrand, Thomas
- Marquette, Jean-Pierre
- Michot, Nadine
- Benard, Tsiala
- Perrin, Marc-Antoine
- Lemaitre, Olivier
- Guerif, Stephane
- Perron, Sébastien
- Monget, Sylvie
- Gruss-Leleu, Florence
- Doerflinger, Gilles
- Guizani, Houlfa
- Brollo, Maurice
- Delbarre, Laurence
- Bertin, Luc
- Richepin, Patrick
- Loyau, Véronique
- Garcia-Echeverria, Carlos
- Lengauer, Christoph
- Schio, Laurent
Producer: 20140415
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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