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Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms. [electronic resource] by
- Leung, Louis
- Yang, Xin
- Strelevitz, Timothy J
- Montgomery, Justin
- Brown, Matthew F
- Zientek, Michael A
- Banfield, Christopher
- Gilbert, Adam M
- Thorarensen, Atli
- Dowty, Martin E
Producer: 20180221
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 45
Availability: No items available.
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The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a TYK2/JAK1 Inhibitor (PF-06700841) in Healthy Subjects and Patients With Plaque Psoriasis. [electronic resource] by
- Banfield, Christopher
- Scaramozza, Matthew
- Zhang, Weidong
- Kieras, Elizabeth
- Page, Karen M
- Fensome, Andrew
- Vincent, Michael
- Dowty, Martin E
- Goteti, Kosalaram
- Winkle, Peter J
- Peeva, Elena
Producer: 20190503
In:
Journal of clinical pharmacology vol. 58
Availability: No items available.
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12.
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Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists. [electronic resource] by
- Meyers, Kenneth M
- Méndez-Andino, José
- Colson, Anny-Odile
- Hu, X Eric
- Wos, John A
- Mitchell, Maria C
- Hodge, Karen
- Howard, Jeremy
- Paris, Jennifer L
- Dowty, Martin E
- Obringer, Cindy M
- Reizes, Ofer
Producer: 20070403
In:
Bioorganic & medicinal chemistry letters vol. 17
Availability: No items available.
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Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies. [electronic resource] by
- Avery, Lindsay B
- Wang, Mengmeng
- Kavosi, Mania S
- Joyce, Alison
- Kurz, Jeffrey C
- Fan, Yao-Yun
- Dowty, Martin E
- Zhang, Minlei
- Zhang, Yiqun
- Cheng, Aili
- Hua, Fei
- Jones, Hannah M
- Neubert, Hendrik
- Polzer, Robert J
- O'Hara, Denise M
Producer: 20171206
In:
mAbs vol. 8
Availability: No items available.
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14.
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Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic approach. [electronic resource] by
- Tian, Xinrong
- Field, Timothy B
- Switzer, Adrian G
- Mazur, Adam W
- Ebetino, Frank H
- Wos, John A
- Berberich, Steve M
- Jayasinghe, Lalith R
- Obringer, Cindy M
- Dowty, Martin E
- Pinney, Beth B
- Farmer, Julie A
- Crossdoersen, Doreen
- Sheldon, Russell J
Producer: 20060831
In:
Journal of medicinal chemistry vol. 49
Availability: No items available.
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15.
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Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. [electronic resource] by
- Meyer, Debra M
- Jesson, Michael I
- Li, Xiong
- Elrick, Mollisa M
- Funckes-Shippy, Christie L
- Warner, James D
- Gross, Cindy J
- Dowty, Martin E
- Ramaiah, Shashi K
- Hirsch, Jeffrey L
- Saabye, Matthew J
- Barks, Jennifer L
- Kishore, Nandini
- Morris, Dale L
Producer: 20110714
In:
Journal of inflammation (London, England) vol. 7
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16.
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The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists. [electronic resource] by
- Méndez-Andino, José L
- Colson, Anny-Odile
- Meyers, Kenneth M
- Mitchell, Maria C
- Hodge, Karen
- Howard, Jeremy M
- Kim, Nicholas
- Ackley, David C
- Holbert, Jerry K
- Mittelstadt, Scott W
- Dowty, Martin E
- Obringer, Cindy M
- Suchanek, Paula
- Reizes, Ofer
- Hu, X Eric
- Wos, John A
Producer: 20070504
In:
Bioorganic & medicinal chemistry vol. 15
Availability: No items available.
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17.
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Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists--Increasing selectivity over hERG. [electronic resource] by
- Meyers, Kenneth M
- Méndez-Andino, José L
- Colson, Anny-Odile
- Warshakoon, Namal C
- Wos, John A
- Mitchell, Maria C
- Hodge, Karen M
- Howard, Jeremy M
- Ackley, David C
- Holbert, Jerry K
- Mittelstadt, Scott W
- Dowty, Martin E
- Obringer, Cindy M
- Reizes, Ofer
- Hu, X Eric
Producer: 20070403
In:
Bioorganic & medicinal chemistry letters vol. 17
Availability: No items available.
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18.
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Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). [electronic resource] by
- Ghoreschi, Kamran
- Jesson, Michael I
- Li, Xiong
- Lee, Jamie L
- Ghosh, Sarbani
- Alsup, Jason W
- Warner, James D
- Tanaka, Masao
- Steward-Tharp, Scott M
- Gadina, Massimo
- Thomas, Craig J
- Minnerly, John C
- Storer, Chad E
- LaBranche, Timothy P
- Radi, Zaher A
- Dowty, Martin E
- Head, Richard D
- Meyer, Debra M
- Kishore, Nandini
- O'Shea, John J
Producer: 20110616
In:
Journal of immunology (Baltimore, Md. : 1950) vol. 186
Availability: No items available.
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19.
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Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents. [electronic resource] by
- Tian, Xinrong
- Switzer, Adrian G
- Derose, Steve A
- Mishra, Rajesh K
- Solinsky, Mark G
- Mumin, Rashid N
- Ebetino, Frank H
- Jayasinghe, Lalith R
- Webster, Mark E
- Colson, Anny-Odile
- Crossdoersen, Doreen
- Pinney, Beth B
- Farmer, Julie A
- Dowty, Martin E
- Obringer, Cindy M
- Cruze, Charles A
- Burklow, Melissa L
- Suchanek, Paula M
- Dong, Lily
- Dirr, Mary Kay
- Sheldon, Russell J
- Wos, John A
Producer: 20081030
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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20.
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Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. [electronic resource] by
- Thorarensen, Atli
- Dowty, Martin E
- Banker, Mary Ellen
- Juba, Brian
- Jussif, Jason
- Lin, Tsung
- Vincent, Fabien
- Czerwinski, Robert M
- Casimiro-Garcia, Agustin
- Unwalla, Ray
- Trujillo, John I
- Liang, Sidney
- Balbo, Paul
- Che, Ye
- Gilbert, Adam M
- Brown, Matthew F
- Hayward, Matthew
- Montgomery, Justin
- Leung, Louis
- Yang, Xin
- Soucy, Sarah
- Hegen, Martin
- Coe, Jotham
- Langille, Jonathan
- Vajdos, Felix
- Chrencik, Jill
- Telliez, Jean-Baptiste
Producer: 20170807
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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