Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms. [electronic resource]
Producer: 20180221Description: 1-7 p. digitalISSN:- 1521-009X
- Algorithms
- Animals
- Drug Evaluation, Preclinical
- Glutathione -- metabolism
- Hepatocytes -- metabolism
- Humans
- In Vitro Techniques
- Male
- Metabolic Clearance Rate
- Mice, Inbred C57BL
- Microsomes, Liver -- metabolism
- Models, Biological
- Pharmaceutical Preparations -- blood
- Plasma -- metabolism
- Predictive Value of Tests
- Protein Binding
- Protein Kinase Inhibitors -- blood
- Rats
- Rats, Sprague-Dawley
- Species Specificity
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Publication Type: Journal Article
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