Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data. [electronic resource]
Producer: 20121119Description: 109-15 p. digitalISSN:- 1365-2125
- Adult
- Cross-Over Studies
- Cytochrome P-450 CYP3A -- metabolism
- Drug Interactions
- Female
- GABA Modulators -- pharmacokinetics
- Half-Life
- Humans
- Janus Kinases -- antagonists & inhibitors
- Male
- Metabolic Clearance Rate
- Midazolam -- pharmacokinetics
- Middle Aged
- Piperidines
- Pyrimidines -- pharmacology
- Pyrroles -- pharmacology
- Young Adult
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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