Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease. [electronic resource]
Producer: 20171016Description: 34 p. digitalISSN:- 1758-9193
- Alzheimer Disease -- drug therapy
- Amyloid Precursor Protein Secretases -- metabolism
- Amyloid beta-Peptides -- metabolism
- Animals
- Brain -- drug effects
- Cell Line, Tumor
- Drug Evaluation, Preclinical
- HEK293 Cells
- HeLa Cells
- Heterocyclic Compounds, 4 or More Rings -- pharmacokinetics
- Humans
- Male
- Mice
- Mice, 129 Strain
- Mutation
- Neocortex -- drug effects
- Nootropic Agents -- pharmacokinetics
- Presenilin-1 -- genetics
- Rats, Wistar
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Publication Type: Journal Article
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