Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
Blain, Jean-François
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease. [electronic resource] - Alzheimer's research & therapy 08 2016 - 34 p. digital
Publication Type: Journal Article
1758-9193
10.1186/s13195-016-0199-5 doi
Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases--metabolism
Amyloid beta-Peptides--metabolism
Animals
Brain--drug effects
Cell Line, Tumor
Drug Evaluation, Preclinical
HEK293 Cells
HeLa Cells
Heterocyclic Compounds, 4 or More Rings--pharmacokinetics
Humans
Male
Mice
Mice, 129 Strain
Mutation
Neocortex--drug effects
Nootropic Agents--pharmacokinetics
Presenilin-1--genetics
Rats, Wistar
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease. [electronic resource] - Alzheimer's research & therapy 08 2016 - 34 p. digital
Publication Type: Journal Article
1758-9193
10.1186/s13195-016-0199-5 doi
Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases--metabolism
Amyloid beta-Peptides--metabolism
Animals
Brain--drug effects
Cell Line, Tumor
Drug Evaluation, Preclinical
HEK293 Cells
HeLa Cells
Heterocyclic Compounds, 4 or More Rings--pharmacokinetics
Humans
Male
Mice
Mice, 129 Strain
Mutation
Neocortex--drug effects
Nootropic Agents--pharmacokinetics
Presenilin-1--genetics
Rats, Wistar