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The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells. [electronic resource] by
- Bright, Sandra A
- Greene, Lisa M
- Greene, Tom F
- Campiani, Giuseppe
- Butini, Stefania
- Brindisi, Margherita
- Lawler, Mark
- Meegan, Mary J
- Williams, D Clive
- Zisterer, Daniela M
Producer: 20090212
In:
Biochemical pharmacology vol. 77
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SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study). [electronic resource] by
- Langer, Corey J
- Redman, Mary W
- Wade, James L
- Aggarwal, Charu
- Bradley, Jeffrey D
- Crawford, Jeffrey
- Stella, Philip J
- Knapp, Mark H
- Miao, Jieling
- Minichiello, Katherine
- Herbst, Roy S
- Kelly, Karen
- Gandara, David R
- Papadimitrakopoulou, Vassiliki A
Producer: 20200716
In:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer vol. 14
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Phase I Dose-Escalation Study of Taselisib, an Oral PI3K Inhibitor, in Patients with Advanced Solid Tumors. [electronic resource] by
- Juric, Dejan
- Krop, Ian
- Ramanathan, Ramesh K
- Wilson, Timothy R
- Ware, Joseph A
- Sanabria Bohorquez, Sandra M
- Savage, Heidi M
- Sampath, Deepak
- Salphati, Laurent
- Lin, Ray S
- Jin, Huan
- Parmar, Hema
- Hsu, Jerry Y
- Von Hoff, Daniel D
- Baselga, José
Producer: 20180329
In:
Cancer discovery vol. 7
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TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR [electronic resource] by
- Lehmann, Brian D
- Abramson, Vandana G
- Sanders, Melinda E
- Mayer, Erica L
- Haddad, Tufia C
- Nanda, Rita
- Van Poznak, Catherine
- Storniolo, Anna Maria
- Nangia, Julie R
- Gonzalez-Ericsson, Paula I
- Sanchez, Violeta
- Johnson, Kimberly N
- Abramson, Richard G
- Chen, Sheau-Chiann
- Shyr, Yu
- Arteaga, Carlos L
- Wolff, Antonio C
- Pietenpol, Jennifer A
Producer: 20210205
In:
Clinical cancer research : an official journal of the American Association for Cancer Research vol. 26
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Response to Inhibition of Receptor-Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo-Controlled Study. [electronic resource] by
- Weisel, Kathleen
- Berger, Scott
- Papp, Kim
- Maari, Catherine
- Krueger, James G
- Scott, Nicola
- Tompson, Debra
- Wang, Susanne
- Simeoni, Monica
- Bertin, John
- Peter Tak, Paul
Producer: 20210524
In:
Clinical pharmacology and therapeutics vol. 108
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Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. [electronic resource] by
- Picaud, Sarah
- Fedorov, Oleg
- Thanasopoulou, Angeliki
- Leonards, Katharina
- Jones, Katherine
- Meier, Julia
- Olzscha, Heidi
- Monteiro, Octovia
- Martin, Sarah
- Philpott, Martin
- Tumber, Anthony
- Filippakopoulos, Panagis
- Yapp, Clarence
- Wells, Christopher
- Che, Ka Hing
- Bannister, Andrew
- Robson, Samuel
- Kumar, Umesh
- Parr, Nigel
- Lee, Kevin
- Lugo, Dave
- Jeffrey, Philip
- Taylor, Simon
- Vecellio, Matteo L
- Bountra, Chas
- Brennan, Paul E
- O'Mahony, Alison
- Velichko, Sharlene
- Müller, Susanne
- Hay, Duncan
- Daniels, Danette L
- Urh, Marjeta
- La Thangue, Nicholas B
- Kouzarides, Tony
- Prinjha, Rab
- Schwaller, Jürg
- Knapp, Stefan
Producer: 20160426
In:
Cancer research vol. 75
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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. [electronic resource] by
- Harris, Philip A
- King, Bryan W
- Bandyopadhyay, Deepak
- Berger, Scott B
- Campobasso, Nino
- Capriotti, Carol A
- Cox, Julie A
- Dare, Lauren
- Dong, Xiaoyang
- Finger, Joshua N
- Grady, LaShadric C
- Hoffman, Sandra J
- Jeong, Jae U
- Kang, James
- Kasparcova, Viera
- Lakdawala, Ami S
- Lehr, Ruth
- McNulty, Dean E
- Nagilla, Rakesh
- Ouellette, Michael T
- Pao, Christina S
- Rendina, Alan R
- Schaeffer, Michelle C
- Summerfield, Jennifer D
- Swift, Barbara A
- Totoritis, Rachel D
- Ward, Paris
- Zhang, Aming
- Zhang, Daohua
- Marquis, Robert W
- Bertin, John
- Gough, Peter J
Producer: 20160816
In:
Journal of medicinal chemistry vol. 59
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POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients. [electronic resource] by
- Baird, Richard D
- van Rossum, Annelot G J
- Oliveira, Mafalda
- Beelen, Karin
- Gao, Meiling
- Schrier, Mariette
- Mandjes, Ingrid A M
- Garcia-Corbacho, Javier
- Vallier, Anne-Laure
- Dougall, Greig
- van Werkhoven, Erik
- Linossi, Constanza
- Kumar, Sanjeev
- van Tinteren, Harm
- Callari, Maurizio
- Beddowes, Emma
- Perez-Garcia, José-Manuel
- Rosing, Hilde
- Platte, Else
- Nederlof, Petra
- Schot, Margaret
- de Vries Schultink, Aurelia
- Bernards, René
- Saura, Cristina
- Gallagher, William
- Cortès, Javier
- Caldas, Carlos
- Linn, Sabine C
Producer: 20200910
In:
Clinical cancer research : an official journal of the American Association for Cancer Research vol. 25
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Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo. [electronic resource] by
- Bright, S A
- McElligott, A M
- O'Connell, J W
- O'Connor, L
- Carroll, P
- Campiani, G
- Deininger, M W
- Conneally, E
- Lawler, M
- Williams, D C
- Zisterer, D M
Producer: 20100609
In:
British journal of cancer vol. 102
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Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions. [electronic resource] by
- Wei, Xiao-Hong
- Yu, Shan-Dong
- Ren, Lu
- Huang, Si-Hui
- Yang, Qiao-Mei
- Wang, Ping
- Chu, Yan-Peng
- Yang, Wei
- Ding, Yan-Sheng
- Huo, Yong
- Wu, Lin
Producer: 20180905
In:
Scientific reports vol. 7
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240.
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Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. [electronic resource] by
- Mulligan, Jude M
- Greene, Lisa M
- Cloonan, Suzanne
- Mc Gee, Margaret M
- Onnis, Valeria
- Campiani, Giuseppe
- Fattorusso, Caterina
- Lawler, Mark
- Williams, D Clive
- Zisterer, Daniela M
Producer: 20061024
In:
Molecular pharmacology vol. 70
Availability: No items available.
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