Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo. [electronic resource]
Producer: 20100609Description: 1474-82 p. digitalISSN:- 1532-1827
- Adult
- Aged
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Cell Line, Tumor
- Cell Separation
- Cell Survival -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Female
- Flow Cytometry
- Genes, abl -- genetics
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy
- Male
- Mice
- Mice, Inbred BALB C
- Middle Aged
- Mutation
- Oxazepines -- pharmacology
- Pyrroles -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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