Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.
Leung, Louis
Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals 01 2017 - 1-7 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.116.072983 doi
Algorithms
Animals
Drug Evaluation, Preclinical
Glutathione--metabolism
Hepatocytes--metabolism
Humans
In Vitro Techniques
Male
Metabolic Clearance Rate
Mice, Inbred C57BL
Microsomes, Liver--metabolism
Models, Biological
Pharmaceutical Preparations--blood
Plasma--metabolism
Predictive Value of Tests
Protein Binding
Protein Kinase Inhibitors--blood
Rats
Rats, Sprague-Dawley
Species Specificity
Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals 01 2017 - 1-7 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.116.072983 doi
Algorithms
Animals
Drug Evaluation, Preclinical
Glutathione--metabolism
Hepatocytes--metabolism
Humans
In Vitro Techniques
Male
Metabolic Clearance Rate
Mice, Inbred C57BL
Microsomes, Liver--metabolism
Models, Biological
Pharmaceutical Preparations--blood
Plasma--metabolism
Predictive Value of Tests
Protein Binding
Protein Kinase Inhibitors--blood
Rats
Rats, Sprague-Dawley
Species Specificity