IBI302, a promising candidate for AMD treatment, targeting both the VEGF and complement system with high binding affinity in vitro and effective targeting of the ocular tissue in healthy rhesus monkeys. [electronic resource]
Producer: 20170613Description: 352-358 p. digitalISSN:- 1096-0007
- Angiogenesis Inhibitors -- pharmacokinetics
- Animals
- Antibodies, Monoclonal, Humanized -- therapeutic use
- Cell Proliferation -- drug effects
- Complement Activation -- drug effects
- Complement Inactivating Agents -- pharmacokinetics
- Complement System Proteins -- metabolism
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Immunoglobulin Fc Fragments -- pharmacology
- Intravitreal Injections
- Macaca mulatta
- Macular Degeneration -- drug therapy
- Recombinant Fusion Proteins -- pharmacokinetics
- Vascular Endothelial Growth Factor A -- antagonists & inhibitors
- Vitreous Body -- metabolism
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Publication Type: Journal Article
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