IBI302, a promising candidate for AMD treatment, targeting both the VEGF and complement system with high binding affinity in vitro and effective targeting of the ocular tissue in healthy rhesus monkeys.
Ren, Xinyi
IBI302, a promising candidate for AMD treatment, targeting both the VEGF and complement system with high binding affinity in vitro and effective targeting of the ocular tissue in healthy rhesus monkeys. [electronic resource] - Experimental eye research 04 2016 - 352-358 p. digital
Publication Type: Journal Article
1096-0007
10.1016/j.exer.2016.02.004 doi
Angiogenesis Inhibitors--pharmacokinetics
Animals
Antibodies, Monoclonal, Humanized--therapeutic use
Cell Proliferation--drug effects
Complement Activation--drug effects
Complement Inactivating Agents--pharmacokinetics
Complement System Proteins--metabolism
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Immunoglobulin Fc Fragments--pharmacology
Intravitreal Injections
Macaca mulatta
Macular Degeneration--drug therapy
Recombinant Fusion Proteins--pharmacokinetics
Vascular Endothelial Growth Factor A--antagonists & inhibitors
Vitreous Body--metabolism
IBI302, a promising candidate for AMD treatment, targeting both the VEGF and complement system with high binding affinity in vitro and effective targeting of the ocular tissue in healthy rhesus monkeys. [electronic resource] - Experimental eye research 04 2016 - 352-358 p. digital
Publication Type: Journal Article
1096-0007
10.1016/j.exer.2016.02.004 doi
Angiogenesis Inhibitors--pharmacokinetics
Animals
Antibodies, Monoclonal, Humanized--therapeutic use
Cell Proliferation--drug effects
Complement Activation--drug effects
Complement Inactivating Agents--pharmacokinetics
Complement System Proteins--metabolism
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Immunoglobulin Fc Fragments--pharmacology
Intravitreal Injections
Macaca mulatta
Macular Degeneration--drug therapy
Recombinant Fusion Proteins--pharmacokinetics
Vascular Endothelial Growth Factor A--antagonists & inhibitors
Vitreous Body--metabolism