Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ. [electronic resource]
Producer: 20150330Description: 109-17 p. digitalISSN:- 1476-5578
- Alzheimer Disease -- complications
- Amyloid beta-Peptides -- metabolism
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Antipsychotic Agents -- therapeutic use
- Blood-Testis Barrier -- drug effects
- Cells, Cultured
- Cognition Disorders -- drug therapy
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Fibroblasts -- drug effects
- Gangliosides -- metabolism
- Humans
- Maze Learning -- drug effects
- Mice
- Mice, Inbred C57BL
- Mutation -- genetics
- Recognition, Psychology -- drug effects
- Time Factors
- beta-N-Acetylhexosaminidases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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