Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.
Knight, E M
Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ. [electronic resource] - Molecular psychiatry Feb 2015 - 109-17 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5578
10.1038/mp.2014.135 doi
Alzheimer Disease--complications
Amyloid beta-Peptides--metabolism
Amyloid beta-Protein Precursor--genetics
Animals
Antipsychotic Agents--therapeutic use
Blood-Testis Barrier--drug effects
Cells, Cultured
Cognition Disorders--drug therapy
Disease Models, Animal
Dose-Response Relationship, Drug
Fibroblasts--drug effects
Gangliosides--metabolism
Humans
Maze Learning--drug effects
Mice
Mice, Inbred C57BL
Mutation--genetics
Recognition, Psychology--drug effects
Time Factors
beta-N-Acetylhexosaminidases--metabolism
Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ. [electronic resource] - Molecular psychiatry Feb 2015 - 109-17 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5578
10.1038/mp.2014.135 doi
Alzheimer Disease--complications
Amyloid beta-Peptides--metabolism
Amyloid beta-Protein Precursor--genetics
Animals
Antipsychotic Agents--therapeutic use
Blood-Testis Barrier--drug effects
Cells, Cultured
Cognition Disorders--drug therapy
Disease Models, Animal
Dose-Response Relationship, Drug
Fibroblasts--drug effects
Gangliosides--metabolism
Humans
Maze Learning--drug effects
Mice
Mice, Inbred C57BL
Mutation--genetics
Recognition, Psychology--drug effects
Time Factors
beta-N-Acetylhexosaminidases--metabolism