The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents. [electronic resource]
Producer: 20150427Description: 130-46 p. digitalISSN:- 1520-4804
- Administration, Oral
- Animals
- Antineoplastic Agents -- chemistry
- Biological Availability
- Cell Line, Tumor
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Drug Design
- Drug Discovery
- Drug Screening Assays, Antitumor
- HCT116 Cells
- Humans
- Indoles -- chemistry
- MCF-7 Cells
- Mice
- Models, Chemical
- Molecular Structure
- Neoplasms -- drug therapy
- Protein Kinase Inhibitors -- chemistry
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Rats
- Spiro Compounds -- chemistry
- Structure-Activity Relationship
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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