The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
Sampson, Peter B
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents. [electronic resource] - Journal of medicinal chemistry Jan 2015 - 130-46 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm5005336 doi
Administration, Oral
Animals
Antineoplastic Agents--chemistry
Biological Availability
Cell Line, Tumor
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug Design
Drug Discovery
Drug Screening Assays, Antitumor
HCT116 Cells
Humans
Indoles--chemistry
MCF-7 Cells
Mice
Models, Chemical
Molecular Structure
Neoplasms--drug therapy
Protein Kinase Inhibitors--chemistry
Protein Serine-Threonine Kinases--antagonists & inhibitors
Rats
Spiro Compounds--chemistry
Structure-Activity Relationship
Xenograft Model Antitumor Assays
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents. [electronic resource] - Journal of medicinal chemistry Jan 2015 - 130-46 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm5005336 doi
Administration, Oral
Animals
Antineoplastic Agents--chemistry
Biological Availability
Cell Line, Tumor
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug Design
Drug Discovery
Drug Screening Assays, Antitumor
HCT116 Cells
Humans
Indoles--chemistry
MCF-7 Cells
Mice
Models, Chemical
Molecular Structure
Neoplasms--drug therapy
Protein Kinase Inhibitors--chemistry
Protein Serine-Threonine Kinases--antagonists & inhibitors
Rats
Spiro Compounds--chemistry
Structure-Activity Relationship
Xenograft Model Antitumor Assays