The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents. (Record no. 23861651)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02454 a2200757 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250516214128.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201504s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm5005336 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sampson, Peter B |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20150427 |
| 245 00 - TITLE STATEMENT | |
| Title | The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Jan 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 130-46 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article; Research Support, Non-U.S. Gov't |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Administration, Oral |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antineoplastic Agents |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biological Availability |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line, Tumor |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Survival |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dose-Response Relationship, Drug |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Design |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Screening Assays, Antitumor |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HCT116 Cells |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Indoles |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MCF-7 Cells |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Chemical |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Structure |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Neoplasms |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Kinase Inhibitors |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Serine-Threonine Kinases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Spiro Compounds |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Xenograft Model Antitumor Assays |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, Yong |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Patel, Narendra Kumar |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Feher, Miklos |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Forrest, Bryan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, Sze-Wan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Edwards, Louise |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laufer, Radoslaw |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lang, Yunhui |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ban, Fuqiang |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Awrey, Donald E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mao, Guodong |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Plotnikova, Olga |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Leung, Genie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hodgson, Richard |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mason, Jacqueline M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wei, Xin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kiarash, Reza |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Green, Erin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Qiu, Wei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chirgadze, Nickolay Y |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mak, Tak W |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pan, Guohua |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pauls, Henry W |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 58 |
| -- | no. 1 |
| -- | p. 130-46 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm5005336">https://doi.org/10.1021/jm5005336</a> |
| Public note | Available from publisher's website |
No items available.