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  2. Details for: Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.
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Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. [electronic resource]

By:
  • Sofia, Michael J
Contributor(s):
  • Bao, Donghui
  • Chang, Wonsuk
  • Du, Jinfa
  • Nagarathnam, Dhanapalan
  • Rachakonda, Suguna
  • Reddy, P Ganapati
  • Ross, Bruce S
  • Wang, Peiyuan
  • Zhang, Hai-Ren
  • Bansal, Shalini
  • Espiritu, Christine
  • Keilman, Meg
  • Lam, Angela M
  • Steuer, Holly M Micolochick
  • Niu, Congrong
  • Otto, Michael J
  • Furman, Phillip A
Producer: 20101109Description: 7202-18 p. digitalISSN:
  • 1520-4804
Subject(s):
  • Animals
  • Antiviral Agents -- chemical synthesis
  • Cell Line
  • Crystallography, X-Ray
  • Dogs
  • Drug Resistance, Viral
  • Esters
  • Hepacivirus -- drug effects
  • Hepatocytes -- metabolism
  • Humans
  • In Vitro Techniques
  • Liver -- metabolism
  • Macaca fascicularis
  • Mutation
  • Prodrugs -- chemical synthesis
  • Rats
  • Replicon
  • Sofosbuvir
  • Stereoisomerism
  • Structure-Activity Relationship
  • Uridine Monophosphate -- analogs & derivatives
  • Viral Nonstructural Proteins -- antagonists & inhibitors
Online resources:
  • Available from publisher's website
In: Journal of medicinal chemistry vol. 53
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Publication Type: Journal Article

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Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

APA

Sofia M. J., Bao D., Chang W., Du J., Nagarathnam D., Rachakonda S., Reddy P. G., Ross B. S., Wang P., Zhang H., Bansal S., Espiritu C., Keilman M., Lam A. M., Steuer H. M. M., Niu C., Otto M. J. & Furman P. A. (20101109). Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. : Journal of medicinal chemistry.

Chicago

Sofia Michael J, Bao Donghui, Chang Wonsuk, Du Jinfa, Nagarathnam Dhanapalan, Rachakonda Suguna, Reddy P Ganapati, Ross Bruce S, Wang Peiyuan, Zhang Hai-Ren, Bansal Shalini, Espiritu Christine, Keilman Meg, Lam Angela M, Steuer Holly M Micolochick, Niu Congrong, Otto Michael J and Furman Phillip A. 20101109. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. : Journal of medicinal chemistry.

Harvard

Sofia M. J., Bao D., Chang W., Du J., Nagarathnam D., Rachakonda S., Reddy P. G., Ross B. S., Wang P., Zhang H., Bansal S., Espiritu C., Keilman M., Lam A. M., Steuer H. M. M., Niu C., Otto M. J. and Furman P. A. (20101109). Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. : Journal of medicinal chemistry.

MLA

Sofia Michael J, Bao Donghui, Chang Wonsuk, Du Jinfa, Nagarathnam Dhanapalan, Rachakonda Suguna, Reddy P Ganapati, Ross Bruce S, Wang Peiyuan, Zhang Hai-Ren, Bansal Shalini, Espiritu Christine, Keilman Meg, Lam Angela M, Steuer Holly M Micolochick, Niu Congrong, Otto Michael J and Furman Phillip A. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. : Journal of medicinal chemistry. 20101109.

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