Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. [electronic resource]
Producer: 20101109Description: 7202-18 p. digitalISSN:- 1520-4804
- Animals
- Antiviral Agents -- chemical synthesis
- Cell Line
- Crystallography, X-Ray
- Dogs
- Drug Resistance, Viral
- Esters
- Hepacivirus -- drug effects
- Hepatocytes -- metabolism
- Humans
- In Vitro Techniques
- Liver -- metabolism
- Macaca fascicularis
- Mutation
- Prodrugs -- chemical synthesis
- Rats
- Replicon
- Sofosbuvir
- Stereoisomerism
- Structure-Activity Relationship
- Uridine Monophosphate -- analogs & derivatives
- Viral Nonstructural Proteins -- antagonists & inhibitors
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Publication Type: Journal Article
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