Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Sofia, Michael J

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. [electronic resource] - Journal of medicinal chemistry Oct 2010 - 7202-18 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm100863x doi


Animals
Antiviral Agents--chemical synthesis
Cell Line
Crystallography, X-Ray
Dogs
Drug Resistance, Viral
Esters
Hepacivirus--drug effects
Hepatocytes--metabolism
Humans
In Vitro Techniques
Liver--metabolism
Macaca fascicularis
Mutation
Prodrugs--chemical synthesis
Rats
Replicon
Sofosbuvir
Stereoisomerism
Structure-Activity Relationship
Uridine Monophosphate--analogs & derivatives
Viral Nonstructural Proteins--antagonists & inhibitors