Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. (Record no. 20176445)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02117 a2200661 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250516002554.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201011s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm100863x |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sofia, Michael J |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20101109 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Oct 2010 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 7202-18 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antiviral Agents |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Crystallography, X-Ray |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dogs |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Resistance, Viral |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Esters |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Hepacivirus |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Hepatocytes |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | In Vitro Techniques |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Liver |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Macaca fascicularis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mutation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Prodrugs |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Replicon |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Sofosbuvir |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Stereoisomerism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Uridine Monophosphate |
| General subdivision | analogs & derivatives |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Viral Nonstructural Proteins |
| General subdivision | antagonists & inhibitors |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bao, Donghui |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chang, Wonsuk |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Du, Jinfa |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nagarathnam, Dhanapalan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rachakonda, Suguna |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reddy, P Ganapati |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ross, Bruce S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Peiyuan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Hai-Ren |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bansal, Shalini |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Espiritu, Christine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Keilman, Meg |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lam, Angela M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Steuer, Holly M Micolochick |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Niu, Congrong |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Otto, Michael J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Furman, Phillip A |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 53 |
| -- | no. 19 |
| -- | p. 7202-18 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm100863x">https://doi.org/10.1021/jm100863x</a> |
| Public note | Available from publisher's website |
No items available.