Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. [electronic resource]
Producer: 20100504Description: 2666-70 p. digitalISSN:- 1520-4804
- Animals
- Area Under Curve
- Binding, Competitive
- CHO Cells
- Carboxylic Acids -- chemistry
- Cricetinae
- Cricetulus
- Cyclohexanecarboxylic Acids -- chemistry
- Cyclohexenes -- chemistry
- Dogs
- Drug Discovery
- Drug Evaluation, Preclinical
- Fatty Acids, Nonesterified -- blood
- Humans
- Metabolic Clearance Rate
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Models, Chemical
- Molecular Structure
- Oxadiazoles -- chemistry
- Rats
- Receptors, G-Protein-Coupled -- agonists
- Receptors, Nicotinic -- genetics
- Structure-Activity Relationship
- Vasodilation -- drug effects
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Publication Type: Journal Article
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