Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

Shen, Hong C

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. [electronic resource] - Journal of medicinal chemistry Mar 2010 - 2666-70 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm100022r doi


Animals
Area Under Curve
Binding, Competitive
CHO Cells
Carboxylic Acids--chemistry
Cricetinae
Cricetulus
Cyclohexanecarboxylic Acids--chemistry
Cyclohexenes--chemistry
Dogs
Drug Discovery
Drug Evaluation, Preclinical
Fatty Acids, Nonesterified--blood
Humans
Metabolic Clearance Rate
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Chemical
Molecular Structure
Oxadiazoles--chemistry
Rats
Receptors, G-Protein-Coupled--agonists
Receptors, Nicotinic--genetics
Structure-Activity Relationship
Vasodilation--drug effects