Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. (Record no. 19552707)
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| fixed length control field | 02494 a2200781 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250515210614.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201005s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm100022r |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shen, Hong C |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20100504 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Mar 2010 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 2666-70 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Area Under Curve |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Binding, Competitive |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CHO Cells |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Carboxylic Acids |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cricetinae |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cricetulus |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cyclohexanecarboxylic Acids |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cyclohexenes |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dogs |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Evaluation, Preclinical |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Fatty Acids, Nonesterified |
| General subdivision | blood |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Metabolic Clearance Rate |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Inbred C57BL |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Knockout |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Chemical |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Structure |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Oxadiazoles |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Receptors, G-Protein-Coupled |
| General subdivision | agonists |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Receptors, Nicotinic |
| General subdivision | genetics |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Vasodilation |
| General subdivision | drug effects |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ding, Fa-Xiang |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Raghavan, Subharekha |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Deng, Qiaolin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Luell, Silvi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Forrest, Michael J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Carballo-Jane, Ester |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wilsie, Larissa C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Krsmanovic, Mihajlo L |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Taggart, Andrew K |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wu, Kenneth K |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wu, Tsuei-Ju |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cheng, Kang |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ren, Ning |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cai, Tian-Quan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Qing |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Junying |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wolff, Michael S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tong, Xinchun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Holt, Tom G |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Waters, M Gerard |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hammond, Milton L |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tata, James R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Colletti, Steven L |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 53 |
| -- | no. 6 |
| -- | p. 2666-70 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm100022r">https://doi.org/10.1021/jm100022r</a> |
| Public note | Available from publisher's website |
No items available.