Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). [electronic resource]
Producer: 20080512Description: 1288-92 p. digitalISSN:- 1464-3405
- ADAM Proteins -- antagonists & inhibitors
- ADAM17 Protein
- Administration, Oral
- Alkanes -- chemical synthesis
- Animals
- Biological Availability
- Caco-2 Cells
- Humans
- Hydroxamic Acids -- chemical synthesis
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases -- metabolism
- Models, Molecular
- Protease Inhibitors -- chemical synthesis
- Rats
- Rats, Sprague-Dawley
- Spiro Compounds -- chemical synthesis
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Publication Type: Journal Article
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