Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Ott, Gregory R

Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). [electronic resource] - Bioorganic & medicinal chemistry letters Feb 2008 - 1288-92 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2008.01.030 doi


ADAM Proteins--antagonists & inhibitors
ADAM17 Protein
Administration, Oral
Alkanes--chemical synthesis
Animals
Biological Availability
Caco-2 Cells
Humans
Hydroxamic Acids--chemical synthesis
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases--metabolism
Models, Molecular
Protease Inhibitors--chemical synthesis
Rats
Rats, Sprague-Dawley
Spiro Compounds--chemical synthesis