Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. [electronic resource]
Producer: 20010927Description: 2933-49 p. digitalISSN:- 0022-2623
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Animals
- Antineoplastic Agents -- chemical synthesis
- Binding Sites
- Binding, Competitive
- Biological Availability
- Cell Line, Transformed
- Dogs
- Drug Design
- Drug Screening Assays, Antitumor
- Enzyme Inhibitors -- chemical synthesis
- Farnesyltranstransferase
- Genes, ras
- Imidazoles -- chemical synthesis
- Lactams -- chemical synthesis
- Mice
- Mice, Transgenic
- Models, Molecular
- Neoplasms, Experimental -- pathology
- Nitriles -- chemical synthesis
- Pyrrolidinones -- chemical synthesis
- Radioligand Assay
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article
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