Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.

Bell, I M

Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. [electronic resource] - Journal of medicinal chemistry Aug 2001 - 2933-49 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm010156p doi


Alkyl and Aryl Transferases--antagonists & inhibitors
Animals
Antineoplastic Agents--chemical synthesis
Binding Sites
Binding, Competitive
Biological Availability
Cell Line, Transformed
Dogs
Drug Design
Drug Screening Assays, Antitumor
Enzyme Inhibitors--chemical synthesis
Farnesyltranstransferase
Genes, ras
Imidazoles--chemical synthesis
Lactams--chemical synthesis
Mice
Mice, Transgenic
Models, Molecular
Neoplasms, Experimental--pathology
Nitriles--chemical synthesis
Pyrrolidinones--chemical synthesis
Radioligand Assay
Stereoisomerism
Structure-Activity Relationship