Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. (Record no. 11444560)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02488 a2200769 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250514005740.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200109s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0022-2623 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm010156p |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bell, I M |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20010927 |
| 245 00 - TITLE STATEMENT | |
| Title | Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Aug 2001 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 2933-49 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Alkyl and Aryl Transferases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antineoplastic Agents |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Binding Sites |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Binding, Competitive |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biological Availability |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line, Transformed |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dogs |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Design |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Screening Assays, Antitumor |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Enzyme Inhibitors |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Farnesyltranstransferase |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Genes, ras |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Imidazoles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Lactams |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Transgenic |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Neoplasms, Experimental |
| General subdivision | pathology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nitriles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrrolidinones |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Radioligand Assay |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Stereoisomerism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gallicchio, S N |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abrams, M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Beshore, D C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Buser, C A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Culberson, J C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Davide, J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ellis-Hutchings, M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fernandes, C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gibbs, J B |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Graham, S L |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hartman, G D |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heimbrook, D C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Homnick, C F |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Huff, J R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kassahun, K |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Koblan, K S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kohl, N E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lobell, R B |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lynch, J J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Miller, P A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omer, C A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rodrigues, A D |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walsh, E S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Williams, T M |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 44 |
| -- | no. 18 |
| -- | p. 2933-49 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm010156p">https://doi.org/10.1021/jm010156p</a> |
| Public note | Available from publisher's website |
No items available.