Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.

Steeneck, Christoph

Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach. [electronic resource] - Bioorganic & medicinal chemistry letters 06 2020 - 127174 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2020.127174 doi


Administration, Oral
Amides--administration & dosage
Animals
Dose-Response Relationship, Drug
Drug Discovery
Microsomes, Liver--chemistry
Molecular Structure
Nuclear Receptor Subfamily 1, Group F, Member 3--agonists
Oxadiazoles--administration & dosage
Rats
Structure-Activity Relationship
Thiazoles--administration & dosage