Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.
Intlekofer, Andrew M
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. [electronic resource] - Nature 07 2018 - 125-129 p. digital
Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-4687
10.1038/s41586-018-0251-7 doi
Alleles
Allosteric Site--drug effects
Aminopyridines--chemistry
Animals
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Disease Progression
Drug Resistance, Neoplasm--drug effects
Enzyme Inhibitors--chemistry
Female
Glutamine--genetics
Glutarates--blood
HEK293 Cells
Humans
Isocitrate Dehydrogenase--antagonists & inhibitors
Isoleucine--genetics
Leukemia, Myeloid, Acute--blood
Mice
Mice, Inbred C57BL
Models, Molecular
Mutant Proteins--antagonists & inhibitors
Mutation
Protein Multimerization--genetics
Triazines--chemistry
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. [electronic resource] - Nature 07 2018 - 125-129 p. digital
Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-4687
10.1038/s41586-018-0251-7 doi
Alleles
Allosteric Site--drug effects
Aminopyridines--chemistry
Animals
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Disease Progression
Drug Resistance, Neoplasm--drug effects
Enzyme Inhibitors--chemistry
Female
Glutamine--genetics
Glutarates--blood
HEK293 Cells
Humans
Isocitrate Dehydrogenase--antagonists & inhibitors
Isoleucine--genetics
Leukemia, Myeloid, Acute--blood
Mice
Mice, Inbred C57BL
Models, Molecular
Mutant Proteins--antagonists & inhibitors
Mutation
Protein Multimerization--genetics
Triazines--chemistry