Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Rohde, Jason M

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. [electronic resource] - Bioorganic & medicinal chemistry 05 2018 - 1727-1739 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1464-3391

10.1016/j.bmc.2018.02.016 doi


Dose-Response Relationship, Drug
Drug Discovery
Enzyme Inhibitors--chemical synthesis
High-Throughput Screening Assays
Humans
Molecular Structure
Phosphoglycerate Dehydrogenase--antagonists & inhibitors
Piperazines--chemical synthesis
Structure-Activity Relationship
Thiourea--analogs & derivatives