Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule.
Deng, Gejing
Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. [electronic resource] - The Journal of biological chemistry Jan 2015 - 762-74 p. digital
Publication Type: Journal Article
1083-351X
10.1074/jbc.M114.608497 doi
Allosteric Site
Crystallography, X-Ray
DNA Methylation--genetics
Drug Discovery
Enzyme Inhibitors--chemical synthesis
Escherichia coli
Gene Expression Regulation, Neoplastic
Humans
Isocitrate Dehydrogenase--antagonists & inhibitors
Magnesium--chemistry
Mutant Proteins--chemistry
Neoplasms--drug therapy
Protein Conformation
Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. [electronic resource] - The Journal of biological chemistry Jan 2015 - 762-74 p. digital
Publication Type: Journal Article
1083-351X
10.1074/jbc.M114.608497 doi
Allosteric Site
Crystallography, X-Ray
DNA Methylation--genetics
Drug Discovery
Enzyme Inhibitors--chemical synthesis
Escherichia coli
Gene Expression Regulation, Neoplastic
Humans
Isocitrate Dehydrogenase--antagonists & inhibitors
Magnesium--chemistry
Mutant Proteins--chemistry
Neoplasms--drug therapy
Protein Conformation