Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.

Wanngren, Johanna

Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. [electronic resource] - The Journal of biological chemistry Sep 2012 - 32640-50 p. digital

Publication Type: Journal Article

1083-351X

10.1074/jbc.M112.376541 doi


Amyloid--genetics
Amyloid Precursor Protein Secretases--genetics
Amyloid beta-Protein Precursor--genetics
Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Female
Flurbiprofen--pharmacology
HEK293 Cells
Humans
Mice
Protein Processing, Post-Translational--drug effects
Protein Structure, Tertiary
Receptors, Notch--genetics
Sulindac--analogs & derivatives