Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.

Chan, C C

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. [electronic resource] - The Journal of pharmacology and experimental therapeutics Aug 1999 - 551-60 p. digital

Publication Type: Journal Article

0022-3565


12-Hydroxy-5,8,10,14-eicosatetraenoic Acid--metabolism
Animals
Arachidonate 15-Lipoxygenase--metabolism
Arachidonic Acid--metabolism
Arthritis, Experimental--blood
Blood Platelets--drug effects
COS Cells
Cell Line
Cricetinae
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors--pharmacology
Digestive System--drug effects
Dogs
Edema--chemically induced
Female
Humans
Hyperalgesia--chemically induced
In Vitro Techniques
Isoenzymes--metabolism
Lactones--pharmacology
Leukotriene B4--biosynthesis
Male
Membrane Proteins
Microsomes--drug effects
Prostaglandin-Endoperoxide Synthases--metabolism
Rats
Rats, Inbred Lew
Saimiri
Sulfones