Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. [electronic resource]
Producer: 19990818Description: 551-60 p. digitalISSN:- 0022-3565
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid -- metabolism
- Animals
- Arachidonate 15-Lipoxygenase -- metabolism
- Arachidonic Acid -- metabolism
- Arthritis, Experimental -- blood
- Blood Platelets -- drug effects
- COS Cells
- Cell Line
- Cricetinae
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors -- pharmacology
- Digestive System -- drug effects
- Dogs
- Edema -- chemically induced
- Female
- Humans
- Hyperalgesia -- chemically induced
- In Vitro Techniques
- Isoenzymes -- metabolism
- Lactones -- pharmacology
- Leukotriene B4 -- biosynthesis
- Male
- Membrane Proteins
- Microsomes -- drug effects
- Prostaglandin-Endoperoxide Synthases -- metabolism
- Rats
- Rats, Inbred Lew
- Saimiri
- Sulfones
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Publication Type: Journal Article
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