Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. [electronic resource]
Producer: 20190624Description: 2385 p. digitalISSN:- 2041-1723
- Antineoplastic Agents -- metabolism
- Bridged Bicyclo Compounds, Heterocyclic -- metabolism
- Crystallization
- Crystallography, X-Ray
- Drug Resistance, Neoplasm -- genetics
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Mutation
- Protein Binding
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Sulfonamides -- metabolism
- Surface Plasmon Resonance
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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