Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.

Birkinshaw, Richard W

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. [electronic resource] - Nature communications 06 2019 - 2385 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-1723

10.1038/s41467-019-10363-1 doi


Antineoplastic Agents--metabolism
Bridged Bicyclo Compounds, Heterocyclic--metabolism
Crystallization
Crystallography, X-Ray
Drug Resistance, Neoplasm--genetics
Humans
Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy
Mutation
Protein Binding
Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors
Sulfonamides--metabolism
Surface Plasmon Resonance