Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. [electronic resource]
Producer: 20010628Description: 3361-9 p. digitalISSN:- 0006-4971
- Adult
- Aged
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Bone Marrow -- metabolism
- Cohort Studies
- Dose-Response Relationship, Drug
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- adverse effects
- Farnesyltranstransferase
- Female
- Genes, ras
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy
- Leukemia, Myeloid, Acute -- drug therapy
- Male
- Middle Aged
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases -- metabolism
- Mutation
- Phosphorylation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Protein Prenylation
- Quinolones -- adverse effects
- Recurrence
- Remission Induction
- Treatment Outcome
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Publication Type: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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