Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial.

Karp, J E

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. [electronic resource] - Blood Jun 2001 - 3361-9 p. digital

Publication Type: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0006-4971

10.1182/blood.v97.11.3361 doi


Adult
Aged
Alkyl and Aryl Transferases--antagonists & inhibitors
Bone Marrow--metabolism
Cohort Studies
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Enzyme Inhibitors--adverse effects
Farnesyltranstransferase
Female
Genes, ras
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Leukemia, Myeloid, Acute--drug therapy
Male
Middle Aged
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--metabolism
Mutation
Phosphorylation
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Protein Prenylation
Quinolones--adverse effects
Recurrence
Remission Induction
Treatment Outcome