The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. [electronic resource]
Producer: 20150428Description: 250-6 p. digitalISSN:- 1546-1718
- Adaptor Proteins, Signal Transducing -- genetics
- Animals
- Biomarkers, Tumor -- genetics
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- genetics
- Female
- Gene Knockdown Techniques
- Genes, ras
- HEK293 Cells
- HT29 Cells
- Heterografts
- Hippo Signaling Pathway
- Humans
- MAP Kinase Kinase Kinases -- antagonists & inhibitors
- MAP Kinase Signaling System -- drug effects
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Molecular Targeted Therapy
- Mutation
- Phosphoproteins -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- genetics
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Transcription Factors
- YAP-Signaling Proteins
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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