The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
Lin, Luping
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. [electronic resource] - Nature genetics Mar 2015 - 250-6 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1546-1718
10.1038/ng.3218 doi
Adaptor Proteins, Signal Transducing--genetics
Animals
Biomarkers, Tumor--genetics
Cell Line, Tumor
Drug Resistance, Neoplasm--genetics
Female
Gene Knockdown Techniques
Genes, ras
HEK293 Cells
HT29 Cells
Heterografts
Hippo Signaling Pathway
Humans
MAP Kinase Kinase Kinases--antagonists & inhibitors
MAP Kinase Signaling System--drug effects
Mice
Mice, Inbred NOD
Mice, SCID
Molecular Targeted Therapy
Mutation
Phosphoproteins--genetics
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--genetics
Proto-Oncogene Proteins B-raf--antagonists & inhibitors
Transcription Factors
YAP-Signaling Proteins
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. [electronic resource] - Nature genetics Mar 2015 - 250-6 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1546-1718
10.1038/ng.3218 doi
Adaptor Proteins, Signal Transducing--genetics
Animals
Biomarkers, Tumor--genetics
Cell Line, Tumor
Drug Resistance, Neoplasm--genetics
Female
Gene Knockdown Techniques
Genes, ras
HEK293 Cells
HT29 Cells
Heterografts
Hippo Signaling Pathway
Humans
MAP Kinase Kinase Kinases--antagonists & inhibitors
MAP Kinase Signaling System--drug effects
Mice
Mice, Inbred NOD
Mice, SCID
Molecular Targeted Therapy
Mutation
Phosphoproteins--genetics
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--genetics
Proto-Oncogene Proteins B-raf--antagonists & inhibitors
Transcription Factors
YAP-Signaling Proteins