A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node--ablated, His bundle-paced dog. [electronic resource]
Producer: 20060223Description: 1-10 p. digitalISSN:- 1056-8719
- Animals
- Anti-Arrhythmia Agents -- blood
- Atrioventricular Node -- surgery
- Bundle of His -- surgery
- Cardiac Pacing, Artificial
- Catheter Ablation
- Cisapride -- blood
- Dogs
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical -- methods
- Electrocardiography -- drug effects
- Gastrointestinal Agents -- blood
- Histamine H1 Antagonists -- blood
- Ion Channels -- antagonists & inhibitors
- Long QT Syndrome -- etiology
- Male
- Models, Animal
- Models, Biological
- Piperidines -- blood
- Pyridines -- blood
- Terfenadine -- blood
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Publication Type: Journal Article
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